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News from PLOSOne

Risks of tinnitus, sensorineural hearing impairment, and sudden deafness in patients with non-migraine headache

by Yi-Chun Chen, Shiang-Jiun Tsai, Jin-Cherng Chen, Juen-Haur Hwang
Tinnitus and hearing impairment are prevalent among headache patients. This study aims to investigate the risk of tinnitus, sensorineural hearing impairment, and sudden deafness in patients with non-migraine headache. Participants included 43 294 patients with non-migraine headache (non-migraine headache cohort) and 173 176 patients with no headache of any type (control cohort) frequency-matched with respect to 10-year age ...

Source: PLOSOne
Published: Fri, 06 Sep 2019 23:00 UTC

Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models

by Weihua Wang, Li. S. Zhang, Alexander K. Zinsmaier, Genevieve Patterson, Emily Jean Leptich, Savannah L. Shoemaker, Tatiana A. Yatskievych, Robert Gibboni, Edward Pace, Hao Luo, Jinsheng Zhang, Sungchil Yang, Shaowen Bao
Hearing loss is a major risk factor for tinnitus, hyperacusis, and central auditory processing disorder. Although recent studies indicate that hearing loss causes neuroinflammation in the auditory pathway, the mechanisms underlying hearing loss–related pathologies are still ...

Source: PLOSOne
Published: Tue, 18 Jun 2019 23:00 UTC

Individual knock out of glycine receptor alpha subunits identifies a specific requirement of glra1 for motor function in zebrafish

by Eric Samarut, Domitille Chalopin, Raphaëlle Riché, Marc Allard, Meijiang Liao, Pierre Drapeau
Glycine receptors (GlyRs) are ligand-gated chloride channels mediating inhibitory neurotransmission in the brain stem and spinal cord. They function as pentamers composed of alpha and beta subunits for which 5 genes have been identified in human (GLRA1, GLRA2, GLRA3, GLRA4, GLRB). Several in vitro studies showed that the pentameric subtype composition as well as its stoichiometry influence the ...

Source: PLOSOne
Published: Thu, 02 May 2019 23:00 UTC

BOLD fMRI effects of transcutaneous vagus nerve stimulation in patients with chronic tinnitus

by Natalia Yakunina, Sam Soo Kim, Eui-Cheol Nam
Objective Vagus nerve stimulation (VNS) is a neuromodulation method used for treatment of epilepsy and depression. Transcutaneous VNS (tVNS) has been gaining popularity as a noninvasive alternative to VNS. Previous tVNS neuroimaging studies revealed brain (de)activation patterns that involved multiple areas implicated in tinnitus generation and perception. In this study, functional magnetic resonance imaging (fMRI) was used to explore the effects of ...

Source: PLOSOne
Published: Wed, 28 Nov 2018 23:00 UTC

Prevalence and relationship of olfactory dysfunction and tinnitus among middle- and old-aged population in Korea

by Do-Yang Park, Hyun Jun Kim, Chang-Hoon Kim, Jae Yong Lee, Kyungdo Han, Ji Ho Choi
Olfactory dysfunction and tinnitus are age-related otorhinolaryngological disorders with a high prevalence in the elderly population and share several common clinical features. However, there is no study investigating the relationship between these two diseases. We studied the prevalence of olfactory dysfunction and tinnitus among Koreans and studied the relationship between these two diseases based on the Korean ...

Source: PLOSOne
Published: Tue, 23 Oct 2018 23:00 UTC

Changes in spontaneous movement in response to silent gaps are not robust enough to indicate the perception of tinnitus in mice

by Daniël O. J. Reijntjes, Nick M. A. Schubert, Alexander Pietrus-Rajman, Pim van Dijk, Sonja J. Pyott
Approaches to identify the perception of tinnitus in various animal models have been difficult to apply to mouse. As a result, mice have been underutilized to investigate the cellular, molecular, and genetic mechanisms underlying tinnitus. A recent study in guinea pigs identified a novel spontaneous behavior (unconditioned response), changes in movement during silent gaps, that identified a ...

Source: PLOSOne
Published: Wed, 29 Aug 2018 23:00 UTC

Subtyping patients with somatic tinnitus: Modulation of tinnitus and history for somatic dysfunction help identify tinnitus patients with temporomandibular joint disorders

by Massimo Ralli, Antonio Greco, Armando Boccassini, Giancarlo Altissimi, Carlo Di Paolo, Vincenzo Falasca, Armando De Virgilio, Antonella Polimeni, Giancarlo Cianfrone, Marco de Vincentiis
Objective Determine in a cohort of patients with normal hearing and chronic tinnitus if self-reported history for temporomandibular joint (TMJ) dysfunction and a positive modulation of tinnitus in the TMJ region could be suggestive of an underlying TMJ disorder.
Patients and methods The study included 226 ...

Source: PLOSOne
Published: Mon, 13 Aug 2018 23:00 UTC

Subtyping patients with somatic tinnitus: Modulation of tinnitus and history for somatic dysfunction help identify tinnitus patients with temporomandibular joint disorders

by Massimo Ralli, Antonio Greco, Armando Boccassini, Giancarlo Altissimi, Carlo Di Paolo, Vincenzo Falasca, Armando De Virgilio, Antonella Polimeni, Giancarlo Cianfrone, Marco de Vincentiis
Objective Determine in a cohort of patients with normal hearing and chronic tinnitus if self-reported history for temporomandibular joint (TMJ) dysfunction and a positive modulation of tinnitus in the TMJ region could be suggestive of an underlying TMJ disorder.
Patients and methods The study included 226 ...

Source: PLOSOne
Published: Mon, 13 Aug 2018 23:00 UTC

Recruiting and retaining participants in e-Delphi surveys for core outcome set development: Evaluating the COMiT'ID study

by Deborah Ann Hall, Harriet Smith, Eithne Heffernan, Kathryn Fackrell, for the Core Outcome Measures in Tinnitus International Delphi (COMiT’ID) Research Steering Group
Background A Core Outcome Set (COS) is an agreed list of outcomes that are measured and reported in all clinical trials for a particular health condition. An ‘e-Delphi’ is an increasingly popular method for developing a COS whereby stakeholders are consulted via a multi-round online survey to reach agreement regarding the most ...

Source: PLOSOne
Published: Mon, 30 Jul 2018 23:00 UTC

Recruiting and retaining participants in e-Delphi surveys for core outcome set development: Evaluating the COMiT'ID study

by Deborah Ann Hall, Harriet Smith, Eithne Heffernan, Kathryn Fackrell, for the Core Outcome Measures in Tinnitus International Delphi (COMiT’ID) Research Steering Group
Background A Core Outcome Set (COS) is an agreed list of outcomes that are measured and reported in all clinical trials for a particular health condition. An ‘e-Delphi’ is an increasingly popular method for developing a COS whereby stakeholders are consulted via a multi-round online survey to reach agreement regarding the most ...

Source: PLOSOne
Published: Mon, 30 Jul 2018 23:00 UTC


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